Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 2/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30801304 | 0.86 | PARP1 (0.64) | PARP1NPC1RAB9ASMN1; SMN2AR | |
| SCHEMBL248215 | 0.86 | PARP1 (0.64) | PARP1NPC1RAB9ASMN1; SMN2AR | |
| SCHEMBL4488379 | 0.83 | PARP1 (0.52) | PARP1ARLMNAENPP1MAPK10 | |
| SCHEMBL154687 | 0.83 | LMNA (0.49) | PARP1NPC1RAB9ASMN1; SMN2AR | |
| SCHEMBL28116839 | 0.83 | MAPK10 (0.46) | PARP1ARLMNAENPP1MAPK10 | |
| SCHEMBL7122967 | 0.81 | AR (0.77) | PARP1ARLMNAENPP1CYP3A4 | |
| SCHEMBL694563 | 0.80 | PARP1 (0.46) | PARP1NPC1RAB9ASMN1; SMN2AR | |
| SCHEMBL694505 | 0.80 | PARP1 (0.45) | PARP1ARLMNAENPP1KDM4E | |
| SCHEMBL28098683 | 0.80 | CNR1 (0.62) | PARP1ARLMNAMAPK10MAPK8 | |
| SCHEMBL14979171 | 0.77 | MEN1 (0.55) | PARP1NPC1RAB9ASMN1; SMN2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |