Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Paricalcitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR known ✓ | P11473 | 13/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.57 |
| ▸ | PGR | P06401 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paricalcitol SCHEMBL12915640 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL14491013 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL12464943 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL12397908 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL25447329 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL21836180 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL24066861 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL12535671 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL17354891 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 | |
| Paricalcitol SCHEMBL12553223 | 1.00 | VDR (0.68) | VDRHDAC6HDAC3HDAC2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675838-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | Puretecch LYT, Inc. (US) | 2020-07-08 | — | — | EP | disclosed |
| WO-2019046491-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | ARIYA THERAPEUTICS, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| EP-1267856-A2 | TREATMENT OF ICU-ASSOCIATED HYPOCALCEMIA WITH VITAMIN D COMPOUNDS | Abbott Laboratories (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001076578-A2 | TREATMENT OF ICU-ASSOCIATED HYPOCALCEMIA WITH VITAMIN D COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-10-18 | — | — | WO | disclosed |