Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 15/20 | 0.80 |
| ▸ | PTPRC | P08575 | 3/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951733 | 0.89 | PTPN1 (1.00) | PTPN1PTPRC | |
| SCHEMBL6946532 | 0.88 | PTPN1 (0.97) | PTPN1PTPRC | |
| SCHEMBL6943560 | 0.85 | PTPN1 (1.00) | PTPN1PTPRC | |
| SCHEMBL6946310 | 0.84 | PTPN1 (0.88) | PTPN1PTPRC | |
| SCHEMBL6944037 | 0.83 | PTPN1 (0.86) | PTPN1PTPRC | |
| SCHEMBL7886888 | 0.82 | PTPN1 (0.53) | PTPN1PTPRCMAOA | |
| SCHEMBL6951395 | 0.81 | PTPN1 (0.51) | PTPN1PTPRCMAOA | |
| SCHEMBL6946443 | 0.81 | PTPN1 (0.53) | PTPN1PTPRC | |
| SCHEMBL7165563 | 0.81 | PTPN1 (0.77) | PTPN1PTPRC | |
| SCHEMBL7159975 | 0.80 | PTPN1 (0.80) | PTPN1PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | claimed |
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |