Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.53 |
| ▸ | CA12 | O43570 | 14/20 | 0.44 |
| ▸ | CA1 | P00915 | 14/20 | 0.44 |
| ▸ | CA2 | P00918 | 14/20 | 0.44 |
| ▸ | CA4 | P22748 | 14/20 | 0.44 |
| ▸ | CA5A | P35218 | 14/20 | 0.44 |
| ▸ | CA7 | P43166 | 14/20 | 0.44 |
| ▸ | CA9 | Q16790 | 14/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 14/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948321 | 0.90 | PTPN1 (0.61) | PTPN1PTPRC | |
| SCHEMBL7884360 | 0.85 | PTPN1 (0.75) | PTPN1PTPRC | |
| SCHEMBL6946012 | 0.81 | PTPN1 (0.80) | PTPN1PTPRC | |
| SCHEMBL7161145 | 0.80 | PTPN1 (0.69) | PTPN1PTPRC | |
| SCHEMBL7888262 | 0.78 | PTPN1 (0.56) | PTPN1CA12CA1CA2CA4 | |
| SCHEMBL6944056 | 0.77 | PTPN1 (0.62) | PTPN1PTPRC | |
| SCHEMBL7165297 | 0.77 | PTPN1 (0.54) | PTPN1PTPRC | |
| SCHEMBL6946043 | 0.77 | CA2 (0.45) | CA12CA1CA2CA4CA5A | |
| SCHEMBL6948696 | 0.77 | PTPN1 (0.61) | PTPN1PTPRC | |
| SCHEMBL6951395 | 0.77 | PTPN1 (0.51) | PTPN1CA12CA1CA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |