Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031428 | 0.82 | ALDH1A1 (0.54) | CA12CA1CA2CA4CA7 | |
| SCHEMBL6151978 | 0.78 | ALDH1A1 (0.62) | POLBKMT2AGAAMEN1HPGD | |
| SCHEMBL709788 | 0.77 | POLB (0.68) | POLBKMT2ACA12CA1CA2 | |
| SCHEMBL29391544 | 0.77 | POLB (0.68) | POLBKMT2ACA12CA1CA2 | |
| SCHEMBL1270521 | 0.76 | ALDH1A1 (0.55) | CA12CA1CA2CA4CA7 | |
| SCHEMBL1401811 | 0.76 | CTNNB1 (0.58) | POLBKMT2AGAAMEN1HPGD | |
| SCHEMBL8954755 | 0.75 | CLCN2 (0.50) | HPGDALDH1A1HSD17B10MAPK1KDM4E | |
| Ammonia Solution, Strong SCHEMBL28040603 | 0.75 | POLB (0.65) | POLBKMT2ACA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL6682455 | 0.75 | POLB (0.65) | POLBKMT2ACA12CA1CA2 | |
| SCHEMBL28409820 | 0.75 | POLB (0.65) | POLBKMT2ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268396-A1 | DIPHENYL ETHER COMPOUNDS USEFUL IN THERAPY | Pfizer Limited (GB) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072687-A1 | DIPHENYL ETHER COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2001-10-04 | — | — | WO | disclosed |