Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA2 | P00918 | 5/20 | 0.38 |
| ▸ | CA9 | Q16790 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | TYMP | P19971 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724605 | 0.83 | KMT2A (0.56) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL13065837 | 0.82 | KMT2A (0.61) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL12396375 | 0.81 | KMT2A (0.78) | KMT2ALMNATHRBCYP2C19CA12 | |
| Misonidazole SCHEMBL51943 | 0.81 | KMT2A (0.66) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL6358623 | 0.80 | KMT2A (0.53) | KMT2ALMNATHRBCYP2C19CA12 | |
| [18F]Fluoromisonidazole SCHEMBL13020421 | 0.79 | KMT2A (0.67) | KMT2ALMNATHRBCYP2C19CA12 | |
| [18F]Fluoromisonidazole SCHEMBL18401354 | 0.79 | KMT2A (0.67) | KMT2ALMNATHRBCYP2C19CA12 | |
| [18F]Fluoromisonidazole SCHEMBL17022268 | 0.79 | KMT2A (0.67) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL1614950 | 0.79 | KMT2A (0.67) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL2358150 | 0.79 | KMT2A (0.71) | KMT2ALMNATHRBCYP2C19CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086068-A | Immunochemical detection of hypoxia in normal and tumor tissue | ALBERTA CANCER BOARD (CA) | 1992-02-04 | — | — | US | claimed |
| US-20240165197-A1 | H-NOX PROTEINS FOR TREATING CARDIOVASCULAR AND PULMONARY CONDITIONS | OMNIOX, INC. | 2024-05-23 | — | — | US | disclosed |
| CN-114478489-B | Preparation method and application of fluorine-19 modified nitroimidazole compound and derivative thereof | 中国科学院精密测量科学与技术创新研究院 | 2023-04-28 | — | — | CN | disclosed |
| CN-114478489-A | Preparation method and application of fluorine-19 modified nitroimidazole compound and derivative thereof | 中国科学院精密测量科学与技术创新研究院 | 2022-05-13 | — | — | CN | disclosed |
| US-10357577-B2 | Bacterial nitroreductase enzymes and methods relating thereto | AUCKLAND UNISERVICES LIMITED (NZ) | 2019-07-23 | — | — | US | disclosed |
| US-20130295011-A1 | BACTERIAL NITROREDUCTASE ENZYMES AND METHODS RELATING THERETO | VICTORIA LINK LIMITED (NZ) | 2013-11-07 | — | — | US | disclosed |
| US-20130295011-A1 | BACTERIAL NITROREDUCTASE ENZYMES AND METHODS RELATING THERETO | VICTORIA LINK LIMITED (NZ) | 2013-11-07 | — | — | US | disclosed |
| EP-0669913-B1 | DETECTION OF HYPOXIA | UNIV PENNSYLVANIA (US) | 2003-03-05 | — | — | EP | disclosed |
| US-5843404-A | Immunogenic conjugates of nitroaromatic compounds and proteins; monoclonal antibodies specific for nitroaromatic compounds , their protein conjugates | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0669913-A4 | DETECTION OF HYPOXIA. | UNIV PENNSYLVANIA (US) | 1996-08-21 | — | — | EP | disclosed |
| US-5540908-A | DETECTION OF OXYGEN DEPRIVATION USING IMMUNOHISTOLOGICAL METHODS | THE TRUSTEES OF THE UNIV. OF PENNSYLVANIA (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0669913-A1 | DETECTION OF HYPOXIA | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1995-09-06 | — | — | EP | disclosed |
| WO-1994011348-A1 | DETECTION OF HYPOXIA | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1994-05-26 | — | — | WO | disclosed |
| US-5086068-A | Immunochemical detection of hypoxia in normal and tumor tissue | ALBERTA CANCER BOARD (CA) | 1992-02-04 | — | — | US | disclosed |