Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 8/20 | 0.33 |
| ▸ | MMP3 | P08254 | 6/20 | 0.33 |
| ▸ | MMP7 | P09237 | 5/20 | 0.33 |
| ▸ | MMP1 | P03956 | 5/20 | 0.33 |
| ▸ | MMP9 | P14780 | 3/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946881 | 1.00 | ADAM17 (0.44) | ADAM17MEN1ALDH1A1LMNATSHR | |
| SCHEMBL6946875 | 1.00 | ADAM17 (0.44) | ADAM17MEN1ALDH1A1LMNATSHR | |
| SCHEMBL6946872 | 1.00 | ADAM17 (0.44) | ADAM17MEN1ALDH1A1LMNATSHR | |
| SCHEMBL6943026 | 0.88 | ADAM17 (0.56) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6943031 | 0.88 | ADAM17 (0.56) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6943017 | 0.88 | ADAM17 (0.56) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL7940327 | 0.88 | ADAM17 (0.56) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6943037 | 0.88 | ADAM17 (0.56) | ADAM17MMP2MMP3MMP7MMP1 | |
| SCHEMBL6220231 | 0.88 | ADAM17 (0.43) | ADAM17TSHRKMT2ACTRB1MMP2 | |
| SCHEMBL6220232 | 0.88 | ADAM17 (0.43) | ADAM17TSHRKMT2ACTRB1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |