Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 7/20 | 0.43 |
| ▸ | MMP2 | P08253 | 6/20 | 0.34 |
| ▸ | MMP3 | P08254 | 6/20 | 0.34 |
| ▸ | MMP1 | P03956 | 6/20 | 0.34 |
| ▸ | MMP7 | P09237 | 4/20 | 0.34 |
| ▸ | MMP8 | P22894 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | FCER2 | P06734 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947624 | 0.93 | ADAM17 (0.43) | ADAM17MMP2MMP3MMP1MMP7 | |
| SCHEMBL6942998 | 0.91 | ADAM17 (0.44) | ADAM17MMP2MMP3MMP1MMP7 | |
| SCHEMBL6947093 | 0.91 | ADAM17 (0.46) | ADAM17MMP2MMP3MMP1MMP7 | |
| SCHEMBL8097996 | 0.91 | ADAM17 (0.46) | ADAM17MMP2MMP3MMP1MMP7 | |
| SCHEMBL6941767 | 0.91 | ADAM17 (0.46) | ADAM17MMP2MMP3MMP1MMP7 | |
| SCHEMBL4481740 | 0.89 | ADAM17 (0.46) | ADAM17MMP2MMP3MMP1MMP7 | |
| SCHEMBL6942610 | 0.89 | ADAM17 (0.46) | ADAM17MMP2MMP3MMP1MMP7 | |
| SCHEMBL6947369 | 0.88 | ADAM17 (0.42) | ADAM17MMP2MMP3MMP1MMP7 | |
| SCHEMBL6942446 | 0.87 | ADAM17 (0.46) | ADAM17MMP2MMP3MMP1MMP7 | |
| SCHEMBL6940092 | 0.87 | ADAM17 (0.44) | ADAM17MMP2MMP3MMP1MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |