Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 11/20 | 0.53 |
| ▸ | ERCC5 | P28715 | 10/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.53 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945699 | 0.85 | PTPN1 (0.56) | FEN1ERCC5PTPN1HAO1 | |
| SCHEMBL6948229 | 0.82 | FEN1 (0.61) | FEN1ERCC5PTPN1HAO1 | |
| SCHEMBL6950557 | 0.81 | MRGPRX4 (0.47) | NPC1RAB9ASMN1; SMN2MEN1MITF | |
| SCHEMBL6947650 | 0.80 | PTPN1 (0.72) | FEN1ERCC5PTPN1HAO1NPC1 | |
| SCHEMBL6946193 | 0.79 | PTPN1 (0.67) | FEN1ERCC5PTPN1HAO1SMN1; SMN2 | |
| SCHEMBL6947867 | 0.79 | PTPN1 (0.60) | FEN1ERCC5PTPN1HAO1NPC1 | |
| SCHEMBL6951230 | 0.78 | FEN1 (0.77) | FEN1ERCC5PTPN1HAO1 | |
| Dimethylamine SCHEMBL6943573 | 0.78 | PTPN1 (0.69) | FEN1ERCC5PTPN1HAO1 | |
| SCHEMBL6948009 | 0.77 | PTPN1 (0.57) | FEN1ERCC5PTPN1HAO1MEN1 | |
| SCHEMBL6940911 | 0.77 | PTPN1 (0.72) | FEN1ERCC5PTPN1HAO1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |