Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5962530 | 0.86 | MAOB (0.41) | HTR2ASLC6A4ADRB3CYP2C9TSHR | |
| SCHEMBL16385735 | 0.82 | LMNA (0.42) | KMT2ASMN1; SMN2HTR2ASLC6A4KCNH2 | |
| SCHEMBL19121641 | 0.79 | KMT2A (0.39) | KMT2ASMN1; SMN2HTR2ASLC6A4KCNH2 | |
| SCHEMBL19122238 | 0.79 | KMT2A (0.39) | KMT2ASMN1; SMN2HTR2ASLC6A4KCNH2 | |
| SCHEMBL19541454 | 0.76 | HTR2A (0.42) | KMT2AHTR2ASLC6A4KCNH2RAB9A | |
| SCHEMBL13218297 | 0.76 | TSHR (0.43) | KMT2ACYP2C9TSHRMEN1L3MBTL1 | |
| SCHEMBL12093486 | 0.76 | NQO1 (0.52) | KMT2ASMN1; SMN2HTR2ASLC6A4KCNH2 | |
| SCHEMBL773176 | 0.76 | KMT2A (0.68) | KMT2ASMN1; SMN2ADRB3TSHRMEN1 | |
| SCHEMBL8256695 | 0.75 | PDE2A (0.43) | HTR2ASLC6A4KCNH2GRIN2BCARM1 | |
| SCHEMBL12804702 | 0.75 | CA12 (0.41) | KMT2ACYP2C9TSHRMEN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901483-B1 | BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS | GLAXO GROUP LTD (GB) | 2003-07-09 | — | — | EP | disclosed |
| US-5981572-A | Benzofurans and benzopyrans as chronobiological agents | GLAXO WELLCOME INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0901483-A2 | BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS | GLAXO GROUP LIMITED (GB) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043272-A2 | BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS | GLAXO GROUP LIMITED (GB) | 1997-11-20 | — | — | WO | disclosed |