Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 18/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949746 | 0.90 | PLA2G7 (0.47) | PLA2G7PKM | |
| SCHEMBL6943908 | 0.90 | PLA2G7 (0.49) | PLA2G7 | |
| SCHEMBL4552809 | 0.86 | PLA2G7 (0.48) | PLA2G7CYP3A4CYP2D6 | |
| SCHEMBL6951481 | 0.85 | PLA2G7 (0.44) | PLA2G7 | |
| SCHEMBL6947739 | 0.84 | PLA2G7 (0.52) | PLA2G7 | |
| SCHEMBL6949723 | 0.84 | PLA2G7 (0.51) | PLA2G7 | |
| SCHEMBL6947762 | 0.84 | PLA2G7 (0.51) | PLA2G7 | |
| SCHEMBL6954061 | 0.84 | PLA2G7 (0.57) | PLA2G7 | |
| SCHEMBL6952856 | 0.84 | PLA2G7 (0.57) | PLA2G7 | |
| SCHEMBL7008378 | 0.83 | PLA2G7 (0.47) | PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105377-B1 | PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2003-10-08 | — | — | EP | claimed |
| US-6559155-B1 | Phospholipase A2 enzyme Lipoprotein Associated Phospholipase A2 inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-05-06 | — | — | US | claimed |
| EP-1105377-A1 | PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2001-06-13 | — | — | EP | claimed |
| WO-2000010980-A1 | PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-02 | — | — | WO | claimed |
| US-6559155-B1 | Phospholipase A2 enzyme Lipoprotein Associated Phospholipase A2 inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-05-06 | — | — | US | disclosed |