Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MARK3 | P27448 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29100435 | 0.77 | LRRK2 (0.41) | CHEK1AURKAPDPK1CHEK2HSP90AA1 | |
| SCHEMBL6947463 | 0.75 | LRRK2 (0.56) | CHEK1AURKAPDPK1CHEK2HSP90AA1 | |
| Dimethyladenine SCHEMBL152593 | 0.73 | LRRK2 (0.52) | CHEK1AURKAPDPK1CHEK2HSP90AA1 | |
| SCHEMBL6517684 | 0.72 | LRRK2 (0.42) | CHEK1AURKAPDPK1CHEK2HSP90AA1 | |
| Dimethyladenine SCHEMBL11157543 | 0.72 | LRRK2 (0.50) | CHEK1AURKAPDPK1CHEK2HSP90AA1 | |
| Dimethyladenine SCHEMBL28476806 | 0.72 | LRRK2 (0.50) | CHEK1AURKAPDPK1CHEK2HSP90AA1 | |
| SCHEMBL401115 | 0.70 | CHEK1 (0.37) | CHEK1AURKAPDPK1CHEK2HSP90AA1 | |
| SCHEMBL10700195 | 0.70 | CHEK1 (0.37) | CHEK1AURKAPDPK1CHEK2HSP90AA1 | |
| SCHEMBL5019515 | 0.69 | HTT (0.41) | CHEK1AURKAPDPK1CHEK2HSP90AA1 | |
| SCHEMBL5019519 | 0.68 | HSD17B10 (0.39) | CHEK1AURKAPDPK1CHEK2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986396-A4 | PRION PROTEIN MODULATOR FACTOR (PPMF) AND PRION RESISTANT ANIMALS | UNIV CALIFORNIA (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-0986396-A1 | PRION PROTEIN MODULATOR FACTOR (PPMF) AND PRION RESISTANT ANIMALS | The Regents of the University of California (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998055132-A1 | PRION PROTEIN MODULATOR FACTOR (PPMF) AND PRION RESISTANT ANIMALS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-10 | — | — | WO | disclosed |