Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MARK3 | P27448 | 1/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.56 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 7/20 | 0.49 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 2/20 | 0.47 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30544086 | 0.75 | LRRK2 (0.67) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL6947460 | 0.75 | CHEK1 (0.31) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL30602928 | 0.73 | LRRK2 (0.73) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL6517686 | 0.73 | LRRK2 (0.73) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL9203099 | 0.72 | HTT (0.62) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL152594 | 0.72 | LRRK2 (1.00) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL29349831 | 0.72 | LRRK2 (1.00) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL11157548 | 0.70 | PDPK1 (0.96) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL31439422 | 0.70 | HTT (0.59) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL3038560 | 0.68 | EGFR (0.60) | LRRK2PDPK1CHEK1AURKACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986396-A4 | PRION PROTEIN MODULATOR FACTOR (PPMF) AND PRION RESISTANT ANIMALS | UNIV CALIFORNIA (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-0986396-A1 | PRION PROTEIN MODULATOR FACTOR (PPMF) AND PRION RESISTANT ANIMALS | The Regents of the University of California (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998055132-A1 | PRION PROTEIN MODULATOR FACTOR (PPMF) AND PRION RESISTANT ANIMALS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-10 | — | — | WO | disclosed |