Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9652330 | 0.84 | ALDH1A1 (0.51) | BRD4KDM4EALDH1A1PKMMTNR1A | |
| SCHEMBL3287743 | 0.84 | NPC1 (0.52) | BRD4CYP19A1KDM4EALDH1A1PKM | |
| SCHEMBL6948195 | 0.84 | BRD4 (0.74) | BRD4CYP19A1KDM4EMEN1KMT2A | |
| SCHEMBL3997171 | 0.83 | BRD4 (0.60) | BRD4CYP19A1KDM4EALDH1A1MTNR1A | |
| SCHEMBL6702501 | 0.82 | PTPN1 (0.57) | BRD4KDM4EALDH1A1PKMMTNR1A | |
| SCHEMBL3290045 | 0.82 | PTGDR2 (0.53) | BRD4CYP19A1ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL7649327 | 0.82 | BRD4 (0.70) | BRD4CYP19A1KDM4EMEN1KMT2A | |
| SCHEMBL10659617 | 0.82 | BRD4 (0.70) | BRD4CYP19A1KDM4EMEN1KMT2A | |
| SCHEMBL7646955 | 0.82 | BRD4 (0.74) | BRD4CYP19A1KDM4EMEN1KMT2A | |
| SCHEMBL9432998 | 0.81 | BRD4 (0.59) | BRD4CYP19A1KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649627-B1 | N-Substituted with 1- (pyrid-2-yl)-piperidine-4-yl radical; gastrointestinal and psychological disorder treatment; antidiabetic tocolytic, and antidepressant agents; irritable bowel syndrome, glaucoma and dysmenorrhoea | SANOFI-SYNTHELABO (FR) | 2003-11-18 | — | — | US | disclosed |
| EP-1087961-B1 | PHENOXYLPROPANOLAMINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SANOFI SYNTHELABO (FR) | 2002-08-14 | — | — | EP | disclosed |
| EP-1087961-A1 | PHENOXYLPROPANOLAMINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SANOFI-SYNTHELABO (FR) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065895-A1 | PHENOXYLPROPANOLAMINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SANOFI-SYNTHELABO (FR) | 1999-12-23 | — | — | WO | disclosed |