Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956250 | 0.93 | REN (0.47) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL7082327 | 0.91 | REN (0.42) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7081732 | 0.90 | REN (0.41) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL7082632 | 0.89 | REN (0.46) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL6953120 | 0.89 | REN (0.46) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL6041555 | 0.88 | REN (0.42) | RENKDM4EALDH1A1LMNA | |
| SCHEMBL7075548 | 0.87 | REN (0.58) | REN | |
| SCHEMBL6960072 | 0.87 | REN (0.41) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6955072 | 0.87 | KDM4E (0.42) | RENKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6954945 | 0.87 | REN (0.46) | RENL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |