Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15503686 | 0.84 | SMN1; SMN2 (1.00) | HTTSMN1; SMN2RPS6KB1MAPTLMNA | |
| SCHEMBL6948779 | 0.84 | HTT (0.52) | HTTSMN1; SMN2RPS6KB1MAPTLMNA | |
| SCHEMBL6949468 | 0.84 | HTT (0.52) | HTTSMN1; SMN2RPS6KB1MAPTLMNA | |
| SCHEMBL6949967 | 0.81 | HTT (0.49) | HTTSMN1; SMN2RPS6KB1MAPTLMNA | |
| SCHEMBL6949507 | 0.81 | HTT (0.49) | HTTSMN1; SMN2RPS6KB1MAPTLMNA | |
| SCHEMBL6945564 | 0.78 | HTT (0.46) | HTTSMN1; SMN2RPS6KB1MAPTLMNA | |
| SCHEMBL15503692 | 0.74 | HTT (0.63) | HTTSMN1; SMN2RPS6KB1MAPTLMNA | |
| SCHEMBL958111 | 0.74 | RPS6KB1 (0.53) | HTTSMN1; SMN2RPS6KB1MAPTLMNA | |
| SCHEMBL958110 | 0.74 | RPS6KB1 (0.53) | HTTSMN1; SMN2RPS6KB1MAPTLMNA | |
| SCHEMBL6951060 | 0.73 | HTT (0.44) | HTTSMN1; SMN2MAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074549-B1 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | HOFFMANN LA ROCHE (CH) | 2003-11-19 | — | — | EP | disclosed |
| US-6218385-B1 | FOR THERAPY OR PROPHYLAXIS OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS SUCH AS EPILEPSY, STROKE, CHRONIC AND ACUTE PAIN, PSYCHOSIS, SCHIZOPHRENIA, ALZHEIMER'S DISEASE, COGNITIVE DISORDERS AND MEMORY DEFICITS | HOFFMANN-LA ROCHE INC. | 2001-04-17 | — | — | US | disclosed |
| EP-1074549-A2 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-07 | — | — | EP | disclosed |