Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | HTT | P42858 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958111 | 1.00 | RPS6KB1 (0.53) | RPS6KB1LMNAHTTALDH1A1TSHR | |
| SCHEMBL955635 | 0.83 | LMNA (0.58) | LMNAHTTALDH1A1TSHRMAPT | |
| SCHEMBL955634 | 0.83 | LMNA (0.58) | LMNAHTTALDH1A1TSHRMAPT | |
| SCHEMBL15347529 | 0.75 | CTSK (0.67) | LMNAHTTALDH1A1MAPTKDM4E | |
| SCHEMBL15347528 | 0.75 | CTSK (0.67) | LMNAHTTALDH1A1MAPTKDM4E | |
| SCHEMBL6947729 | 0.74 | HTT (0.73) | RPS6KB1LMNAHTTALDH1A1MAPT | |
| SCHEMBL28765698 | 0.71 | LMNA (0.52) | LMNAHTTALDH1A1TSHRMAPT | |
| SCHEMBL30831365 | 0.71 | DRD2 (0.51) | RPS6KB1LMNAHTTALDH1A1MAPT | |
| SCHEMBL15347078 | 0.70 | CYP1A2 (0.63) | LMNAHTTALDH1A1KDM4EGAA | |
| SCHEMBL15347075 | 0.70 | CYP1A2 (0.63) | LMNAHTTALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103734137-A | Piperazin derivatives and their use in controlling pests | SYNGENTA PARTICIPATIONS AG | 2014-04-23 | — | — | CN | claimed |
| US-20110003991-A1 | PIPERAZINE DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-01-06 | — | — | US | claimed |
| US-20080076777-A1 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | SYNGENTA CROP PROTECTION, INC. (US) | 2008-03-27 | — | — | US | claimed |
| CN-1976586-A | Piperazine derivatives and their use for controlling pests | SYNGENTA PARTICIPATIONS AG (CH) | 2007-06-06 | — | — | CN | claimed |
| EP-1755396-A1 | PIPERAZIN DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | Syngeta Participations AG (CH) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115146-A1 | PIPERAZIN DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2005-12-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003991-A1 | PIPERAZINE DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | CHRM1, CHRM5, PRMT5 | RPS6KB1 1807/4885LMNA 3167/4885HTT 3840/4885 |
| US-20080076777-A1 | 2-chloro-N-(4-chloro-2-{4-[(E)-3-(4-chloro-phenyl)-allyl]-piperazin-1-yl}-phenyl)-isonicotinamide; for insects, acarines, nematodes and molluscs | CHRM1, CHRM2, CHRM5 | RPS6KB1 1462/4885LMNA 3570/4885HTT 1333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.