Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 18/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | PRKCA | P17252 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.40 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949291 | 0.89 | TGFBR1 (0.42) | TGFBR1MAPK14CSNK1DPRKD3MAP4K4 | |
| SCHEMBL7818989 | 0.80 | CYP3A4 (0.38) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7168832 | 0.79 | MAPK14 (0.63) | MAPK14BRD4BRDT | |
| SCHEMBL6799621 | 0.79 | MAPK14 (0.59) | MAPK14CSNK1DPRKD3MAP4K4PRKCA | |
| SCHEMBL6955184 | 0.78 | MAPK14 (0.62) | MAPK14BRD4BRDT | |
| SCHEMBL6951373 | 0.78 | MAPK14 (0.66) | MAPK14BRD4BRDT | |
| SCHEMBL6787715 | 0.78 | MAPK14 (0.60) | MAPK14CSNK1DPRKD3MAP4K4PRKCA | |
| SCHEMBL6943768 | 0.78 | MAPK14 (0.62) | MAPK14BRD4BRDT | |
| SCHEMBL6952383 | 0.78 | MAPK14 (0.64) | MAPK14BRD4BRDT | |
| SCHEMBL6949073 | 0.77 | MAPK14 (0.64) | MAPK14BRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996446-B1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6562832-B1 | Cytokine suppressive anti-inflammatory drugs, capable of inhibiting the CSBP/p38/RK kinase | SMITHKLINE BEECHAM CORPORATION | 2003-05-13 | — | — | US | disclosed |
| US-6046208-A | TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, ENDOTOXEMIA AND/OR TOXIC SHOCK SYNDROME, OTHER ACUTE OR CHRONIC INFLAMMATORY DISEASE STATES SUCH AS THE INFLAMMATORY REACTION INDUCED BY ENDOTOXIN OR INFLAMMATORY BOWEL DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |