Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | EP300 | Q09472 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948078 | 1.00 | KAT8 (0.43) | KAT8KMT2AMEN1SCN2AMAPT | |
| SCHEMBL8425597 | 0.95 | KAT8 (0.40) | KAT8KMT2AMEN1SCN2AMAPT | |
| SCHEMBL8425593 | 0.95 | KAT8 (0.40) | KAT8KMT2AMEN1SCN2AMAPT | |
| SCHEMBL6947878 | 0.89 | KMT2A (0.41) | KAT8KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL6952715 | 0.89 | KMT2A (0.41) | KAT8KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL8425600 | 0.88 | MEN1 (0.43) | KAT8KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL8008959 | 0.86 | KAT8 (0.60) | KAT8KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL6949462 | 0.86 | KAT8 (0.60) | KAT8KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL6952770 | 0.86 | MAPT (0.41) | KAT8KMT2AMEN1SCN2AMAPT | |
| SCHEMBL6952774 | 0.86 | MAPT (0.41) | KAT8KMT2AMEN1SCN2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0743304-A1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | disclosed |