Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.60 |
| ▸ | PTPRC | P08575 | 3/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886821 | 0.93 | PTPN1 (0.70) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7164018 | 0.91 | PTPN1 (0.49) | PTPN1PTPRCPTPN2RAB9AMAPT | |
| SCHEMBL6948682 | 0.88 | PTPN1 (0.63) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7159975 | 0.87 | PTPN1 (0.80) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7169222 | 0.84 | PTPN1 (0.60) | PTPN1PTPRCPTPN2RAB9AMAPT | |
| SCHEMBL7165643 | 0.84 | PTPN1 (0.60) | PTPN1PTPRCPTPN2RAB9AMAPT | |
| SCHEMBL7165440 | 0.82 | PTPN1 (0.56) | PTPN1PTPRCPTPN2MAPTMEN1 | |
| SCHEMBL7164802 | 0.82 | PTPN1 (0.41) | PTPN1PTPRCPTPN2RAB9ACA1 | |
| SCHEMBL7163909 | 0.81 | PTPN1 (0.75) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7166675 | 0.81 | PTPN1 (0.53) | PTPN1PTPRCPTPN2RAB9ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |