Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 15/20 | 0.63 |
| ▸ | PTPRC | P08575 | 3/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | GRB2 | P62993 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886821 | 0.94 | PTPN1 (0.70) | PTPN1PTPRCPTPN2ESRRGCES1 | |
| SCHEMBL6948156 | 0.88 | PTPN1 (0.60) | PTPN1PTPRCPTPN2 | |
| SCHEMBL6946310 | 0.84 | PTPN1 (0.88) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7165440 | 0.84 | PTPN1 (0.56) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7163909 | 0.83 | PTPN1 (0.75) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7886824 | 0.80 | PTPN1 (0.59) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7574524 | 0.79 | PTPN1 (0.50) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7842114 | 0.79 | PTPN1 (0.48) | PTPN1PTPRCPTPN2ESRRGCES1 | |
| SCHEMBL7164018 | 0.79 | PTPN1 (0.49) | PTPN1PTPRCPTPN2 | |
| SCHEMBL6946050 | 0.78 | PTPN1 (0.52) | PTPN1PTPRCPTPN2GRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |