Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.77 |
| ▸ | ERCC5 | P28715 | 9/20 | 0.52 |
| ▸ | FEN1 | P39748 | 9/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947076 | 0.90 | PTPN1 (0.77) | PTPN1ERCC5FEN1SIGMAR1HAO1 | |
| SCHEMBL6943744 | 0.89 | PTPN1 (0.75) | PTPN1ERCC5FEN1HAO1MEN1 | |
| SCHEMBL7072874 | 0.87 | PTPN1 (1.00) | PTPN1ERCC5FEN1HAO1KDM4E | |
| SCHEMBL6943572 | 0.85 | PTPN1 (0.69) | PTPN1ERCC5FEN1HAO1KDM4E | |
| SCHEMBL6943577 | 0.85 | PTPN1 (0.66) | PTPN1ERCC5FEN1HAO1KDM4E | |
| SCHEMBL6946936 | 0.85 | PTPN1 (0.66) | PTPN1ERCC5FEN1HAO1MEN1 | |
| SCHEMBL6951510 | 0.85 | PTPN1 (0.66) | PTPN1ERCC5FEN1HAO1KDM4E | |
| SCHEMBL6949871 | 0.84 | PTPN1 (0.67) | PTPN1ERCC5FEN1HAO1LMNA | |
| SCHEMBL6945641 | 0.84 | PTPN1 (0.71) | PTPN1ERCC5FEN1HAO1 | |
| SCHEMBL6947914 | 0.83 | PTPN1 (0.83) | PTPN1ERCC5FEN1HAO1SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |