Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.69 |
| ▸ | DHODH | Q02127 | 11/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | CLK2 | P49760 | 1/20 | 0.62 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.62 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.62 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.62 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.62 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810422 | 0.90 | PKN1 (0.76) | PARP1DHODHPRKD3MAP4K4PIM1 | |
| SCHEMBL5970048 | 0.88 | DHODH (0.58) | PARP1DHODHPRKD3MAP4K4PIM1 | |
| SCHEMBL7480831 | 0.87 | PKN1 (0.67) | PARP1DHODHPRKD3MAP4K4PIM1 | |
| SCHEMBL7322715 | 0.85 | PKN1 (0.81) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL3580402 | 0.85 | PARP1 (0.69) | PARP1DHODHPRKD3MAP4K4PIM1 | |
| SCHEMBL3574922 | 0.83 | PARP1 (0.56) | PARP1DHODHPRKD3MAP4K4PIM1 | |
| SCHEMBL505325 | 0.83 | PKN1 (0.77) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL7475607 | 0.83 | CBFB (0.63) | PARP1DHODHPRKD3MAP4K4PIM1 | |
| SCHEMBL6170661 | 0.82 | PARP1 (0.64) | PARP1DHODHPRKD3MAP4K4PIM1 | |
| SCHEMBL5886047 | 0.82 | DHODH (0.64) | PARP1DHODHPRKD3MAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |