Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | CLK2 | P49760 | 1/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.58 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.58 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574922 | 0.89 | PARP1 (0.56) | PARP1PRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL6948231 | 0.85 | PARP1 (0.69) | PARP1PRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL7815539 | 0.83 | PARP1 (0.57) | PARP1PKN1PKN2ARMMP2 | |
| SCHEMBL6810422 | 0.83 | PKN1 (0.76) | PARP1PRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL3580405 | 0.83 | MMP2 (0.50) | PARP1ARMMP2MMP9MMP8 | |
| SCHEMBL7259082 | 0.82 | GAA (0.65) | PARP1PRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL29411909 | 0.82 | PARP1 (1.00) | PARP1PRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL7319465 | 0.82 | PARP1 (1.00) | PARP1PRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL6330691 | 0.79 | PARP1 (0.70) | PARP1PKN1PKN2MMP2MMP9 | |
| SCHEMBL6170661 | 0.78 | PARP1 (0.64) | PARP1PRKD3MAP4K4PIM1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |