Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ERCC5 | P28715 | 5/20 | 0.50 |
| ▸ | FEN1 | P39748 | 5/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | GCK | P35557 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935528 | 0.90 | PTPN1 (0.79) | PTPN1MEN1KMT2AERCC5FEN1 | |
| SCHEMBL6947067 | 0.85 | PTPN1 (0.53) | PTPN1MEN1KMT2AERCC5FEN1 | |
| SCHEMBL6947604 | 0.84 | ERCC5 (0.61) | PTPN1ERCC5FEN1HAO1 | |
| SCHEMBL6947647 | 0.84 | PTPN1 (0.70) | PTPN1MEN1KMT2AERCC5FEN1 | |
| SCHEMBL6951325 | 0.83 | PTPN1 (0.49) | PTPN1MEN1KMT2AERCC5FEN1 | |
| SCHEMBL6951340 | 0.82 | PTPN1 (1.00) | PTPN1MEN1KMT2AERCC5FEN1 | |
| SCHEMBL11683646 | 0.80 | PTPN1 (0.72) | PTPN1ERCC5FEN1NR4A2MAOB | |
| SCHEMBL6951989 | 0.80 | PTPN1 (0.46) | PTPN1MEN1KMT2AERCC5FEN1 | |
| SCHEMBL6946229 | 0.80 | PTPN1 (0.84) | PTPN1ERCC5FEN1NR4A2SMPD1 | |
| SCHEMBL13427458 | 0.79 | MEN1 (0.71) | PTPN1MEN1KMT2ANR4A2SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |