Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.39 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.39 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948744 | 0.92 | MAP2K1 (0.54) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6948504 | 0.85 | MAP2K1 (0.62) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6944261 | 0.84 | MAP2K1 (0.49) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6952084 | 0.82 | MAP2K1 (0.47) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6950398 | 0.81 | MAP2K1 (0.46) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6950493 | 0.78 | MAP2K1 (0.43) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL7164337 | 0.77 | MAP2K1 (0.46) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6035272 | 0.77 | MAP2K1 (0.64) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6035416 | 0.76 | MAP2K1 (0.60) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6944361 | 0.76 | MAP2K1 (0.57) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | disclosed |
| US-6506798-B1 | 4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors | WARNER-LAMBERT COMPANY | 2003-01-14 | — | — | US | disclosed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1144362-A1 | 4-ARYLAMINO, 4-ARYLOXY, AND 4-ARYLTHIO DIARYLAMINES AND DERIVATIVES THEREOF AS SELECTIVE MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000041994-A1 | 4-ARYLAMINO, 4-ARYLOXY, AND 4-ARYLTHIO DIARYLAMINES AND DERIVATIVES THEREOF AS SELECTIVE MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |