Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944361 | 0.91 | MAP2K1 (0.57) | MAP2K1CXCR2MAP2K2RAF1PDGFRB | |
| SCHEMBL6951223 | 0.88 | MAP2K1 (0.43) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6948285 | 0.87 | ALDH1A1 (0.42) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6946602 | 0.87 | MAP2K1 (0.42) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6944280 | 0.86 | MAP2K1 (0.57) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6950493 | 0.86 | MAP2K1 (0.43) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6948480 | 0.85 | MAP2K1 (0.44) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6035272 | 0.85 | MAP2K1 (0.64) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6952084 | 0.84 | MAP2K1 (0.47) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6948491 | 0.84 | MAP2K1 (0.47) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | disclosed |
| US-6506798-B1 | 4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors | WARNER-LAMBERT COMPANY | 2003-01-14 | — | — | US | disclosed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1144362-A1 | 4-ARYLAMINO, 4-ARYLOXY, AND 4-ARYLTHIO DIARYLAMINES AND DERIVATIVES THEREOF AS SELECTIVE MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000041994-A1 | 4-ARYLAMINO, 4-ARYLOXY, AND 4-ARYLTHIO DIARYLAMINES AND DERIVATIVES THEREOF AS SELECTIVE MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |