Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6228943 | 0.88 | MAPK13 (0.47) | MAPTALDH1A1KDM4EMAP2K1CLCN2 | |
| SCHEMBL6948311 | 0.87 | CLCN2 (0.52) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5388933 | 0.83 | MAPT (0.51) | MAPTNPC1RAB9AALDH1A1MAP2K1 | |
| SCHEMBL5390982 | 0.82 | MAP2K1 (0.50) | MAP2K1MAP2K2CLCN2MAPK13MAPK12 | |
| SCHEMBL6950018 | 0.81 | MAPT (0.47) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6948913 | 0.81 | MAP2K1 (0.43) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6232920 | 0.80 | MAPK13 (0.45) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL6943933 | 0.80 | MAP2K1 (0.57) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6943879 | 0.78 | KMT2A (0.48) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6944337 | 0.78 | CLCN2 (0.38) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | claimed |
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| CN-1365277-A | Methods of treating chronic pain using MEK inhibitors | VARNER LAMBERT CO (US) | 2002-08-21 | — | — | CN | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |