Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945277 | 0.92 | CHEK1 (0.48) | CHEK1MAPTHSD17B10NTRK1ALDH1A1 | |
| SCHEMBL29828622 | 0.92 | CHEK1 (0.48) | CHEK1MAPTHSD17B10NTRK1ALDH1A1 | |
| SCHEMBL6948771 | 0.84 | MAPT (0.43) | MAPTHSD17B10NTRK1ALDH1A1KDM4E | |
| SCHEMBL7653156 | 0.84 | ALDH1A1 (0.42) | CHEK1MAPTHSD17B10NTRK1ALDH1A1 | |
| SCHEMBL6950391 | 0.82 | CHEK1 (0.52) | CHEK1MAPTHSD17B10NTRK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6949932 | 0.82 | MAPT (0.42) | CHEK1MAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL7654820 | 0.82 | ALDH1A1 (0.50) | CHEK1MAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL7650912 | 0.82 | NPC1 (0.40) | CHEK1MAPTHSD17B10NTRK1KDM4E | |
| SCHEMBL6953837 | 0.82 | CHEK1 (0.43) | CHEK1MAPTHSD17B10NTRK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6953890 | 0.82 | CHEK1 (0.51) | CHEK1MAPTHSD17B10NTRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |