Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 2/20 | 0.57 |
| ▸ | RHOA | P61586 | 2/20 | 0.57 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235847 | 0.83 | SCN8A (0.65) | RHOCRHOASCN8ACYP1A2CYP2D6 | |
| SCHEMBL4256377 | 0.82 | RHOC (0.57) | RHOCRHOASCN8ATACR1MTOR | |
| SCHEMBL3960489 | 0.82 | SCN8A (0.58) | RHOCRHOASCN8AHRH4HRH3 | |
| SCHEMBL6991073 | 0.81 | RHOC (0.56) | RHOCRHOASCN8ATACR1MTOR | |
| SCHEMBL1587762 | 0.81 | TACR1 (0.49) | RHOCRHOASCN8ATACR1MTOR | |
| SCHEMBL5084706 | 0.80 | TACR1 (0.59) | RHOCRHOATACR1MTORIDO1 | |
| SCHEMBL4238709 | 0.79 | SCN8A (0.64) | SCN8AHRH4HRH3SMN1; SMN2CYP1A2 | |
| SCHEMBL4260305 | 0.78 | RHOC (0.53) | RHOCRHOASCN8ATACR1SMN1; SMN2 | |
| SCHEMBL13995257 | 0.77 | XPO1 (0.51) | RHOCRHOASCN8ATACR1MTOR | |
| SCHEMBL3154124 | 0.77 | RHOC (0.49) | RHOCRHOASCN8ATACR1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709376-B1 | Phenylpiperidino derivatives as neurokinin antagonists | ASTRAZENECA AB (SE) | 2003-07-23 | — | — | EP | disclosed |
| EP-0711292-A1 | AZA SPIRO COMPOUNDS ACTING ON THE CHOLINERGIC SYSTEM WITH MUSCARINIC AGONIST ACTIVITY | KOSMIN, Gerald, Emmanuel (GB) | 1996-05-15 | — | — | EP | disclosed |
| EP-0709376-A2 | Therapeutic compounds | ZENECA LIMITED (GB) | 1996-05-01 | — | — | EP | disclosed |