Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508094 | 0.89 | CDK2 (0.46) | CDK2MAPTNPC1MCL1KMT2A | |
| SCHEMBL2846714 | 0.85 | CDK2 (0.56) | CDK2MAPTNPC1MCL1KMT2A | |
| SCHEMBL2075770 | 0.81 | POLB (0.47) | CDK2MAPTNPC1KMT2APOLB | |
| SCHEMBL2852352 | 0.80 | HTT (0.58) | CDK2MAPTNPC1MCL1KMT2A | |
| SCHEMBL7500735 | 0.80 | ALDH1A1 (0.42) | CDK2MAPTNPC1KMT2APOLB | |
| SCHEMBL7502009 | 0.79 | KMT2A (0.41) | CDK2MAPTNPC1KMT2APOLB | |
| SCHEMBL11523840 | 0.78 | CDK2 (0.53) | CDK2MAPTKMT2A | |
| SCHEMBL11523836 | 0.78 | CDK2 (0.53) | CDK2MAPTKMT2A | |
| SCHEMBL2844171 | 0.78 | MAPT (0.59) | MAPTKMT2APOLBL3MBTL1 | |
| SCHEMBL7504662 | 0.77 | KMT2A (0.40) | CDK2MAPTNPC1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064279-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2003-06-25 | — | — | EP | disclosed |
| EP-0915870-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6228877-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2001-05-08 | — | — | US | disclosed |
| EP-1064279-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F.HOFFMANN-LA ROCHE AG (CH) | 2001-01-03 | — | — | EP | disclosed |
| US-6048887-A | 3-(1H-INDOL-3-YL)-4-(1-METHYL-6-NITRO-1H-INDOL-3-YL)-PYRROLE-2,5 -DIONE(AND OTHER DERIVATIVES) AS ANTICARCINOGENIC, ANTITUMOR OR ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1999047518-A1 | SUBSTITUTED BISINDOLYMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-23 | — | — | WO | disclosed |
| EP-0915870-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004551-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-05 | — | — | WO | disclosed |