Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946077 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1ALOX15 | |
| SCHEMBL7505343 | 0.85 | KDM4E (0.52) | PTGS2PTGS1ALOX15 | |
| SCHEMBL7508086 | 0.83 | GRM4 (0.42) | PTGS2 | |
| SCHEMBL7503474 | 0.82 | PTGS2 (0.48) | PTGS2PTGS1ALOX15 | |
| SCHEMBL6170181 | 0.82 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL27532025 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1ALOX15 | |
| SCHEMBL6171070 | 0.81 | PTGS2 (0.48) | PTGS2PTGS1ALOX15 | |
| SCHEMBL6169368 | 0.80 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL6171069 | 0.79 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL7507506 | 0.79 | PTGS2 (0.48) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | claimed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | claimed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | claimed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | claimed |
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | disclosed |
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |