Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 9/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949277 | 1.00 | HMGCR (0.50) | HMGCR | |
| SCHEMBL10442264 | 0.89 | HMGCR (0.51) | HMGCR | |
| SCHEMBL9441815 | 0.86 | HMGCR (0.40) | HMGCR | |
| SCHEMBL9441812 | 0.86 | HMGCR (0.40) | HMGCR | |
| SCHEMBL6944721 | 0.85 | HMGCR (0.40) | HMGCR | |
| SCHEMBL6944717 | 0.85 | HMGCR (0.40) | HMGCR | |
| SCHEMBL10442265 | 0.84 | HMGCR (0.60) | HMGCR | |
| SCHEMBL6950761 | 0.83 | HMGCR (0.58) | HMGCR | |
| SCHEMBL6950766 | 0.83 | HMGCR (0.58) | HMGCR | |
| SCHEMBL10345248 | 0.81 | NR4A2 (0.41) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738512-B1 | Use of a HMG CoA reductase inhibitor to prevent a second heart attack | BRISTOL MYERS SQUIBB CO (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-0738512-A1 | Use of a HMG CoA reductase inhibitor to prevent a second heart attack | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-23 | — | — | EP | disclosed |
| US-5276021-A | Anticholesterol or antilipemic agents | E. R. SQUIBB & SONS, INC. (US) | 1994-01-04 | — | — | US | disclosed |
| US-5091378-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-02-25 | — | — | US | disclosed |