Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9441812 | 1.00 | HMGCR (0.40) | HMGCRALDH1A1NPSR1P2RX7 | |
| SCHEMBL9441767 | 0.87 | FABP4 (0.32) | HMGCRALDH1A1 | |
| SCHEMBL9441760 | 0.87 | FABP4 (0.32) | HMGCRALDH1A1 | |
| SCHEMBL9441625 | 0.86 | HMGCR (0.47) | HMGCRALDH1A1NPSR1P2RX7 | |
| SCHEMBL9441628 | 0.86 | HMGCR (0.47) | HMGCRALDH1A1NPSR1P2RX7 | |
| SCHEMBL6949277 | 0.86 | HMGCR (0.50) | HMGCR | |
| SCHEMBL6949280 | 0.86 | HMGCR (0.50) | HMGCR | |
| SCHEMBL8952837 | 0.84 | NR4A2 (0.32) | HMGCR | |
| SCHEMBL8952841 | 0.84 | NR4A2 (0.32) | HMGCR | |
| SCHEMBL8953026 | 0.83 | HMGCR (0.31) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276021-A | Anticholesterol or antilipemic agents | E. R. SQUIBB & SONS, INC. (US) | 1994-01-04 | — | — | US | disclosed |
| US-5091378-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-02-25 | — | — | US | disclosed |