Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 5/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 3/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15766535 | 1.00 | DNM1 (0.48) | DNM1EPHX2S1PR2S1PR1S1PR3 | |
| SCHEMBL15766252 | 1.00 | DNM1 (0.48) | DNM1EPHX2S1PR2S1PR1S1PR3 | |
| SCHEMBL15766679 | 1.00 | DNM1 (0.48) | DNM1EPHX2S1PR2S1PR1S1PR3 | |
| SCHEMBL6547875 | 1.00 | DNM1 (0.48) | DNM1EPHX2S1PR2S1PR1S1PR3 | |
| SCHEMBL15766251 | 1.00 | DNM1 (0.48) | DNM1EPHX2S1PR2S1PR1S1PR3 | |
| SCHEMBL15766492 | 1.00 | DNM1 (0.48) | DNM1EPHX2S1PR2S1PR1S1PR3 | |
| SCHEMBL6546840 | 0.98 | DNM1 (0.44) | DNM1EPHX2S1PR2S1PR1S1PR3 | |
| SCHEMBL498120 | 0.91 | — | — | |
| SCHEMBL20625249 | 0.81 | EPHX2 (0.62) | DNM1EPHX2S1PR2S1PR1S1PR3 | |
| SCHEMBL11634642 | 0.81 | EPHX2 (0.62) | DNM1EPHX2S1PR2S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105377-B1 | PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2003-10-08 | — | — | EP | disclosed |
| US-6559155-B1 | Phospholipase A2 enzyme Lipoprotein Associated Phospholipase A2 inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-05-06 | — | — | US | disclosed |
| EP-0853077-B1 | Process for producing alkyl 3-amino-4-substituted benzoates | SANKIO CHEMICAL CO LTD (JP) | 2003-04-16 | — | — | EP | disclosed |
| EP-1105377-A1 | PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010980-A1 | PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-02 | — | — | WO | disclosed |
| US-5908955-A | 3-AMINO-4-SUBSTITUTED BENZOIC ACID OR AN ALKALI METAL SALT THEREOF IS ALLOWED TO REACT WITH AN ALKYL HALIDE IN THE PRESENCE OF A BASIC CARBONATE | SANKIO CHEMICAL CO., LTD. (JP) | 1999-06-01 | — | — | US | disclosed |
| EP-0853077-A1 | Process for producing alkyl 3-amino-4-substituted benzoates | Sankio Chemical Co., Ltd. (JP) | 1998-07-15 | — | — | EP | disclosed |