Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 19/20 | 0.81 |
| ▸ | DRD2 | P14416 | 2/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | HTR1D | P28221 | 1/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | HTR1F | P30939 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | HTR6 | P50406 | 1/20 | 0.63 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949854 | 1.00 | UTS2R (0.81) | UTS2RDRD2HTR1ACYP2D6HTR1D | |
| SCHEMBL6953061 | 0.86 | UTS2R (0.62) | UTS2RDRD2HTR1ACYP2D6HTR1D | |
| SCHEMBL6944246 | 0.85 | UTS2R (0.80) | UTS2R | |
| SCHEMBL6948683 | 0.85 | UTS2R (0.80) | UTS2R | |
| SCHEMBL6950192 | 0.80 | UTS2R (0.66) | UTS2RDRD2HTR1ACYP2D6HTR1D | |
| SCHEMBL6950185 | 0.80 | UTS2R (0.66) | UTS2RDRD2HTR1ACYP2D6HTR1D | |
| SCHEMBL6948144 | 0.79 | UTS2R (0.86) | UTS2RDRD2HTR1ACYP2D6HTR1D | |
| SCHEMBL6948138 | 0.79 | UTS2R (0.86) | UTS2RDRD2HTR1ACYP2D6HTR1D | |
| SCHEMBL6596375 | 0.78 | UTS2R (0.52) | UTS2R | |
| SCHEMBL6944305 | 0.77 | UTS2R (1.00) | UTS2RDRD2HTR1ACYP2D6HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244452-B1 | CARBOXAMIDE DERIVATES OF PYRROLIDINE AND PIPERIDINE AS UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | claimed |
| US-6544992-B1 | Carbonylamino pyrrolidine and piperidine derivatives | SMITHKLINE BEECHAM CORPORATION | 2003-04-08 | — | — | US | claimed |
| EP-1244452-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | claimed |
| EP-1244452-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-10-02 | — | — | EP | claimed |
| WO-2001045711-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-28 | — | — | WO | claimed |
| EP-1244452-B1 | CARBOXAMIDE DERIVATES OF PYRROLIDINE AND PIPERIDINE AS UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6544992-B1 | Carbonylamino pyrrolidine and piperidine derivatives | SMITHKLINE BEECHAM CORPORATION | 2003-04-08 | — | — | US | disclosed |