Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 19/20 | 0.61 |
| ▸ | MMP1 | P03956 | 9/20 | 0.61 |
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962710 | 0.90 | MMP3 (0.58) | MMP3MMP1MMP2 | |
| SCHEMBL6950751 | 0.89 | MMP3 (0.64) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL6953747 | 0.84 | MMP3 (0.60) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL6951295 | 0.81 | MMP3 (0.74) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL6950245 | 0.78 | MMP3 (0.51) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL6952846 | 0.77 | MMP3 (0.80) | MMP3MMP1MMP2 | |
| SCHEMBL6952395 | 0.77 | MMP3 (0.78) | MMP3MMP1MMP2 | |
| SCHEMBL6953251 | 0.77 | MMP3 (0.73) | MMP3MMP1MMP2 | |
| SCHEMBL6961005 | 0.77 | MMP3 (0.73) | MMP3MMP1MMP2 | |
| SCHEMBL2680889 | 0.76 | MMP3 (1.00) | MMP3MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900211-B1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | UPJOHN CO (US) | 2003-07-02 | — | — | EP | claimed |
| EP-0900211-A1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-10 | — | — | EP | claimed |
| WO-1997040031-A1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-10-30 | — | — | WO | claimed |
| EP-0900211-B1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | UPJOHN CO (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-0900211-A1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997040031-A1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-10-30 | — | — | WO | disclosed |