Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL272930 | 0.90 | ALDH1A1 (0.42) | HSD17B10TSHRNPC1RAB9ANCF1 | |
| Water SCHEMBL27715056 | 0.88 | ALDH1A1 (0.41) | HSD17B10TSHRNPC1RAB9ANCF1 | |
| SCHEMBL27740774 | 0.88 | ALDH1A1 (0.41) | HSD17B10TSHRNPC1RAB9ANCF1 | |
| Bromide SCHEMBL29723865 | 0.88 | ALDH1A1 (0.41) | HSD17B10TSHRNPC1RAB9ANCF1 | |
| Cyanide SCHEMBL8982602 | 0.85 | ALDH1A1 (0.38) | HSD17B10TSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL28957077 | 0.83 | ALDH1A1 (0.37) | HSD17B10TSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL29684194 | 0.81 | HPRT1 (0.50) | HSD17B10TSHRNPC1RAB9ACYP1A2 | |
| SCHEMBL984030 | 0.81 | HPRT1 (0.50) | HSD17B10TSHRNPC1RAB9ACYP1A2 | |
| Quinoxaline SCHEMBL28443882 | 0.81 | CYP3A4 (0.43) | HSD17B10TSHRNPC1RAB9ACYP1A2 | |
| Benzo[D]Thiazole SCHEMBL7862242 | 0.81 | ALDH1A1 (0.61) | HSD17B10TSHRNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851862-B1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | PHARMACIA ITALIA SPA (IT) | 2003-09-10 | — | — | EP | disclosed |