Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 6/20 | 0.38 |
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946682 | 0.90 | AURKA (0.47) | MAP2K1MEN1KMT2AMAPK1MAP2K2 | |
| SCHEMBL6949203 | 0.90 | MEN1 (0.47) | MAP2K1MEN1KMT2AMAPK1AURKA | |
| SCHEMBL6945746 | 0.85 | MAP2K1 (0.42) | MAP2K1MAP2K2AURKATNFRSF1AKDR | |
| SCHEMBL6944499 | 0.83 | MEN1 (0.62) | MAP2K1MEN1KMT2AMAP2K2PDE4B | |
| SCHEMBL5388205 | 0.82 | MEN1 (0.53) | MAP2K1MEN1KMT2AMAPK1MAP2K2 | |
| SCHEMBL6948517 | 0.81 | MAP2K1 (0.40) | MAP2K1MEN1KMT2AMAPK1MAP2K2 | |
| SCHEMBL6944335 | 0.81 | MAP2K1 (0.41) | MAP2K1MEN1KMT2AMAPK1MAP2K2 | |
| SCHEMBL27585116 | 0.81 | ALDH1A1 (0.40) | MAP2K1PDE4BALDH3A1ALDH1A1ADAM17 | |
| SCHEMBL6946674 | 0.80 | MAP2K1 (0.42) | MAP2K1MEN1KMT2AMAPK1MAP2K2 | |
| SCHEMBL6948716 | 0.78 | AURKA (0.51) | MAP2K1MEN1KMT2AMAPK1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | claimed |
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |