Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.88 |
| ▸ | PDE4A | P27815 | 18/20 | 0.88 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.88 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.88 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950907 | 0.89 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6954576 | 0.89 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7919048 | 0.87 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CGFER | |
| SCHEMBL6950936 | 0.86 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7916544 | 0.86 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8333880 | 0.86 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6836442 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL14043752 | 0.84 | PDE4D (0.74) | PDE4DPDE4APDE4BPDE4CGFER | |
| SCHEMBL5723154 | 0.83 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CGFER | |
| SCHEMBL13741889 | 0.83 | PDE4D (0.83) | PDE4DPDE4APDE4BPDE4CGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| EP-0923568-B9 | NOVEL BENZOFURAN-4-CARBOXAMIDES | ALTANA PHARMA AG (DE) | 2003-08-13 | — | — | EP | disclosed |
| EP-0923568-B1 | NOVEL BENZOFURAN-4-CARBOXAMIDES | ALTANA PHARMA AG (DE) | 2002-12-11 | — | — | EP | disclosed |
| US-6211203-B1 | RESPIRATORY SYSTEM DISORDERS, ANTIINFLAMMATORY AGENTS, ENZYME INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-04-03 | — | — | US | disclosed |
| EP-0923568-A1 | NOVEL BENZOFURAN-4-CARBOXAMIDES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998007715-A9 | NOVEL BENZOFURAN-4-CARBOXAMIDES | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-29 | — | — | WO | disclosed |
| WO-1998007715-A1 | NOVEL BENZOFURAN-4-CARBOXAMIDES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-02-26 | — | — | WO | disclosed |