Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.47 |
| ▸ | RAF1 | P04049 | 4/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585060 | 1.00 | MAPK14 (0.60) | MAPK14CSNK1DJAK3CSNK1A1RPS6KA3 | |
| SCHEMBL4585443 | 0.89 | MAPK14 (0.57) | MAPK14CSNK1DJAK3CSNK1A1RPS6KA3 | |
| SCHEMBL4584925 | 0.89 | MAPK14 (0.61) | MAPK14CSNK1DJAK3CSNK1A1RPS6KA3 | |
| SCHEMBL4583956 | 0.87 | MAPK14 (0.57) | MAPK14CSNK1DJAK3CSNK1A1RPS6KA3 | |
| SCHEMBL8099899 | 0.85 | CSNK1D (0.55) | MAPK14CSNK1DJAK3CSNK1A1RPS6KA3 | |
| SCHEMBL4585531 | 0.84 | MAPK14 (0.57) | MAPK14CSNK1DCSNK1A1RPS6KA3MAPK13 | |
| SCHEMBL4587201 | 0.84 | MAPK14 (0.59) | MAPK14CSNK1DCSNK1A1RPS6KA3MAPK13 | |
| SCHEMBL4583748 | 0.84 | MAPK14 (0.59) | MAPK14CSNK1DCSNK1A1RPS6KA3MAPK13 | |
| SCHEMBL4586046 | 0.84 | MAPK14 (0.59) | MAPK14CSNK1DCSNK1A1RPS6KA3MAPK13 | |
| SCHEMBL8549534 | 0.82 | MAPK14 (0.50) | MAPK14CSNK1DJAK3CSNK1A1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889888-A4 | NOVEL TREATMENT FOR CNS INJURIES | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-0889888-A1 | NOVEL TREATMENT FOR CNS INJURIES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997035856-A1 | NOVEL TREATMENT FOR CNS INJURIES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |