Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554729 | 0.85 | MAPK13 (0.43) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL4585443 | 0.83 | MAPK14 (0.57) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL4025352 | 0.83 | CSNK1A1 (0.60) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL4584849 | 0.83 | CSNK1A1 (0.60) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL6950701 | 0.82 | MAPK14 (0.60) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL4585060 | 0.82 | MAPK14 (0.60) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL5819178 | 0.82 | EGFR (0.46) | ENPP2 | |
| SCHEMBL8551836 | 0.82 | CSNK1A1 (0.46) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL4583956 | 0.80 | MAPK14 (0.57) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL4584925 | 0.80 | MAPK14 (0.61) | MAPK14CSNK1DJAK3MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831830-A4 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0831830-A1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040143-A1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |