Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | UGCG | Q16739 | 2/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957257 | 0.93 | MCHR1 (0.40) | MCHR1KCNH2CYP3A4MAPK14GBA1 | |
| SCHEMBL6956046 | 0.92 | MCHR1 (0.44) | MCHR1KCNH2CYP3A4MAPK14 | |
| SCHEMBL6043024 | 0.87 | MCHR1 (0.41) | MCHR1KCNH2CYP3A4MAPK14 | |
| SCHEMBL6954975 | 0.85 | MCHR1 (0.44) | MCHR1KCNH2CYP3A4MAPK14 | |
| SCHEMBL6041786 | 0.81 | MCHR1 (0.41) | MCHR1KCNH2CYP3A4MAPK14GBA1 | |
| SCHEMBL6959808 | 0.79 | — | — | |
| SCHEMBL6042068 | 0.79 | MAPK14 (0.48) | MCHR1KCNH2CYP3A4MAPK14 | |
| SCHEMBL6951052 | 0.78 | KDM4E (0.44) | KCNH2KDM4EALDH1A1LMNA | |
| SCHEMBL7076673 | 0.76 | REN (0.43) | — | |
| SCHEMBL6951449 | 0.74 | REN (0.49) | KCNH2GBA1UGCGGBA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |