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SCHEMBL6951017

SCHEMBL6951017

COC(=O)C(Cc1ccc(C(F)(F)P(=O)(O)O)cc1)(Cc1ccc(C(F)(F)P(=O)(O)O)cc1)C(=O)OCc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ PTPN1 P18031 17/20 1.00
▸ PTPRC P08575 5/20 0.88
▸ PTPN2 P17706 6/20 0.54
▸ PTPRB P23467 4/20 0.51
▸ PTPN6 P29350 4/20 0.51
▸ PTPN11 Q06124 3/20 0.51
▸ PTPRA P18433 1/20 0.49
▸ CDC25A P30304 1/20 0.49
▸ MEN1 O00255 1/20 0.46
▸ KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6941144 0.95 PTPN1 (0.90) PTPN1PTPRCPTPN2PTPRBPTPN6
SCHEMBL6952067 0.94 PTPN1 (1.00) PTPN1PTPRCPTPN2PTPRBPTPN6
SCHEMBL6951489 0.94 PTPN1 (1.00) PTPN1PTPRCPTPN2PTPRBPTPN6
SCHEMBL6949886 0.88 PTPN1 (1.00) PTPN1PTPRCPTPN2PTPRBPTPN6
SCHEMBL6943702 0.88 PTPN1 (0.88) PTPN1PTPRCPTPN2PTPRBPTPN6
SCHEMBL6951378 0.88 PTPN1 (0.88) PTPN1PTPRCPTPN2PTPRBPTPN6
SCHEMBL6944118 0.87 PTPN1 (0.81) PTPN1PTPRCPTPN2PTPRBPTPN6
SCHEMBL6952150 0.87 PTPN1 (1.00) PTPN1PTPRCPTPN2PTPRBPTPN6
SCHEMBL6944090 0.86 PTPN1 (0.84) PTPN1PTPRCPTPN2PTPRBPTPN6
SCHEMBL6950247 0.86 PTPN1 (0.79) PTPN1PTPRCPTPN2PTPRBPTPN6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115729-B1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B MERCK FROSST CANADA INC (CA) 2003-02-19 — — EP claimed