Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956473 | 0.79 | MAPK1 (0.54) | MAPK1MEN1KMT2A | |
| SCHEMBL20906278 | 0.79 | MAPK1 (0.81) | MAPK1MEN1KMT2A | |
| SCHEMBL113383 | 0.79 | MAPK1 (0.81) | MAPK1MEN1KMT2A | |
| SCHEMBL12593647 | 0.79 | — | — | |
| SCHEMBL6018054 | 0.79 | MAPK1 (0.81) | MAPK1MEN1KMT2A | |
| SCHEMBL113382 | 0.79 | MAPK1 (0.81) | MAPK1MEN1KMT2A | |
| SCHEMBL6962132 | 0.78 | MAPK1 (0.52) | MAPK1MEN1KMT2ABRD4 | |
| Hydrochloric Acid SCHEMBL989897 | 0.77 | MAPK1 (0.77) | MAPK1MEN1KMT2A | |
| SCHEMBL5492918 | 0.76 | MAPK1 (0.50) | MAPK1MEN1KMT2ABRD4 | |
| SCHEMBL6963845 | 0.76 | MAPK1 (0.50) | MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550550-B1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 2003-07-16 | — | — | EP | claimed |
| EP-0550550-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | claimed |
| WO-1992005174-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | claimed |
| EP-0550550-B1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 2003-07-16 | — | — | EP | disclosed |
| EP-0558923-B1 | Diazabicyclo derivatives as 5-HT3 antagonists | NISSHIN FLOUR MILLING CO (JP) | 2000-05-24 | — | — | EP | disclosed |
| EP-0469449-B1 | Diazabicyclononyl derivatives as 5-HT3 receptor antagonists | NISSHIN FLOUR MILLING CO (JP) | 1997-10-01 | — | — | EP | disclosed |
| US-5344831-A | Antiemetics for treatment of nausea from chemotherapy | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| US-5256656-A | Antiserotonine agent | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| EP-0558923-A1 | Diazabicyclo derivatives as 5-HT3 antagonists | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-09-08 | — | — | EP | disclosed |
| EP-0550550-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | disclosed |
| US-5187166-A | Also useful as antipsychotic agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-02-16 | — | — | US | disclosed |
| WO-1992005174-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | disclosed |
| EP-0469449-A1 | Azabicyclo derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-02-05 | — | — | EP | disclosed |