Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13451563 | 0.79 | LMNA (0.41) | MAPK1MEN1KMT2A | |
| SCHEMBL737422 | 0.77 | NR1H2 (0.46) | MAPK1MEN1KMT2AMAPT | |
| SCHEMBL6952003 | 0.76 | MAPK1 (0.60) | MAPK1MEN1KMT2ABRD4 | |
| SCHEMBL19708949 | 0.75 | HTR3A (0.33) | — | |
| SCHEMBL21821171 | 0.74 | CHRNB2 (0.32) | MAPTPOLB | |
| SCHEMBL3398592 | 0.74 | CHRNB2 (0.32) | MAPTPOLB | |
| SCHEMBL2745077 | 0.74 | CHRNB2 (0.32) | MAPTPOLB | |
| Carbamic Acid SCHEMBL12615819 | 0.73 | MAPK1 (0.63) | MAPK1MEN1KMT2A | |
| SCHEMBL6956473 | 0.71 | MAPK1 (0.54) | MAPK1MEN1KMT2AMAPT | |
| SCHEMBL3384724 | 0.71 | CHRNB2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786814-A1 | BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006131884-A2 | THIAZOLE SUBSTITUTED DIAZABICYCLONONANE OR-NONENE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-12-14 | — | — | WO | disclosed |
| WO-2006021402-A1 | BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-03-02 | — | — | WO | disclosed |