SCHEMBL6952094

SCHEMBL6952094

COc1ccc2sc(/C=C/Cn3ccnc3)c(C)c2c1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 4/20 0.46
TBXAS1 P24557 5/20 0.43
QPCT Q16769 1/20 0.41
KMT2A Q03164 2/20 0.39
TP53 P04637 1/20 0.39
MAPK1 P28482 1/20 0.39
CYP11B1 P15538 4/20 0.39
CYP11B2 P19099 4/20 0.39
MEN1 O00255 1/20 0.39
ATM Q13315 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6952102 1.00 CYP19A1 (0.46) CYP19A1TBXAS1QPCTKMT2ATP53
SCHEMBL6960452 0.84 ROCK1 (0.43) CYP19A1TBXAS1QPCTCYP11B1CYP11B2
SCHEMBL6960449 0.84 ROCK1 (0.43) CYP19A1TBXAS1QPCTCYP11B1CYP11B2
SCHEMBL6955408 0.84 CYP19A1 (0.47) CYP19A1TBXAS1CYP11B1CYP11B2
SCHEMBL6955399 0.84 CYP19A1 (0.47) CYP19A1TBXAS1CYP11B1CYP11B2
SCHEMBL6962880 0.76 TUBB4A (0.43) KMT2ATP53MEN1ATM
SCHEMBL6962886 0.76 TUBB4A (0.43) KMT2ATP53MEN1ATM
SCHEMBL6963677 0.74 CYP19A1 (0.60) CYP19A1TBXAS1KMT2ACYP11B1CYP11B2
SCHEMBL6963682 0.74 CYP19A1 (0.60) CYP19A1TBXAS1KMT2ACYP11B1CYP11B2
SCHEMBL6958376 0.70 CYP17A1 (0.34) KMT2ATP53MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0974584-B1 FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-01-15 EP disclosed
US-6420375-B1 ANTITUMOR TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-07-16 US disclosed
EP-0974584-A1 FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-01-26 EP disclosed