Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | MAPT | P10636 | 13/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 9/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952163 | 1.00 | KDM4E (0.68) | KDM4EMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL9525520 | 0.84 | AMY1A (0.63) | MAPTALDH1A1L3MBTL1TDP1HPGD | |
| SCHEMBL9525774 | 0.84 | AMY1A (0.63) | MAPTALDH1A1L3MBTL1TDP1HPGD | |
| SCHEMBL13678890 | 0.83 | KDM4E (0.68) | KDM4EMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL14518012 | 0.83 | KDM4E (0.68) | KDM4EMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL28967916 | 0.82 | KMT2A (0.81) | KDM4EMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL28476008 | 0.82 | KMT2A (0.81) | KDM4EMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL10035997 | 0.82 | KMT2A (0.81) | KDM4EMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL16625533 | 0.81 | KDM4E (0.64) | KDM4EMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL420976 | 0.81 | KDM4E (1.00) | KDM4EMAPTALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274642-B1 | HERBICIDAL AND FUNGICIDAL AGENTS BASED ON SUBSTITUTED PYRAZOLIN-5-ONE DERIVATIVES | BAYER AG (DE) | 1993-08-11 | — | — | EP | claimed |
| US-5162528-A | Pre- and post-emergence; phytaphthora in tomato plants; rice and wheat | BAYER AKTIENGESELLSCHAFT (DE) | 1992-11-10 | — | — | US | claimed |
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |
| CN-1066138-C | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 2001-05-23 | — | — | CN | disclosed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |
| CN-1141291-A | 4-(Arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 1997-01-29 | — | — | CN | disclosed |
| EP-0743304-A1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | disclosed |
| EP-0274642-B1 | HERBICIDAL AND FUNGICIDAL AGENTS BASED ON SUBSTITUTED PYRAZOLIN-5-ONE DERIVATIVES | BAYER AG (DE) | 1993-08-11 | — | — | EP | disclosed |