Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1157761 | 0.85 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1157810 | 0.82 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1157642 | 0.81 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1157535 | 0.80 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27600848 | 0.79 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1157571 | 0.76 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7696540 | 0.76 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369281 | 0.75 | PDE4B (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27521810 | 0.75 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1157724 | 0.74 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353907-A2 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002074726-A2 | ANILINE DERIVATIVES USEFUL AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2002-09-26 | — | — | WO | disclosed |