Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 7/20 | 0.75 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.71 |
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | MTOR | P42345 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.71 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005704 | 1.00 | OPRD1 (0.75) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 | |
| SCHEMBL10832963 | 0.91 | OPRD1 (0.64) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 | |
| SCHEMBL11049779 | 0.89 | OPRD1 (0.59) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 | |
| SCHEMBL6945944 | 0.86 | OPRD1 (0.56) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 | |
| SCHEMBL16433584 | 0.86 | OPRD1 (0.76) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 | |
| SCHEMBL9527954 | 0.86 | OPRD1 (1.00) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 | |
| SCHEMBL9527960 | 0.86 | OPRD1 (1.00) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 | |
| SCHEMBL18790035 | 0.86 | OPRD1 (0.76) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 | |
| SCHEMBL7078419 | 0.86 | OPRD1 (1.00) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 | |
| SCHEMBL6944354 | 0.86 | OPRD1 (0.76) | OPRD1OPRK1OPRM1ALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003526594-A | — | — | 2003-09-09 | — | — | JP | claimed |
| EP-0996434-A4 | KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH | ADOLOR CORP (US) | 2001-10-10 | — | — | EP | claimed |
| EP-0996434-A1 | KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH | Adolor Corporation (US) | 2000-05-03 | — | — | EP | claimed |
| WO-1999003459-A1 | KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH | ADOLOR CORPORATION (US) | 1999-01-28 | — | — | WO | claimed |
| US-4466977-A | N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics | THE UPJOHN COMPANY (US) | 1984-08-21 | — | — | US | claimed |
| EP-0108602-A1 | N-(2-aminocycloalkyl)benzamide and benzeneacetamide derivatives | THE UPJOHN COMPANY (US) | 1984-05-16 | — | — | EP | claimed |
| EP-0996434-A4 | KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH | ADOLOR CORP (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-0996434-A1 | KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH | Adolor Corporation (US) | 2000-05-03 | — | — | EP | disclosed |
| US-6048860-A | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith | ADOLOR CORPORATION (US) | 2000-04-11 | — | — | US | disclosed |
| US-6004964-A | ADMINISTERING AMIDE OR SULFONAMIDE DERIVATIVE; ANALGESICS | ADOLOR CORPORATION (US) | 1999-12-21 | — | — | US | disclosed |
| US-5869521-A | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith | ADOLOR CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |
| WO-1999003459-A1 | KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH | ADOLOR CORPORATION (US) | 1999-01-28 | — | — | WO | disclosed |
| US-5760023-A | CYCLOHEXYLACETAMIDE DERIVATIVES, AGONIST AT KAPPA OPIOD RECEPTORS, TREATMENT OF ITCHING | ADOLOR CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
| US-4466977-A | N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics | THE UPJOHN COMPANY (US) | 1984-08-21 | — | — | US | disclosed |
| US-4466977-A | N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics | THE UPJOHN COMPANY (US) | 1984-08-21 | — | — | US | disclosed |
| EP-0108602-A1 | N-(2-aminocycloalkyl)benzamide and benzeneacetamide derivatives | THE UPJOHN COMPANY (US) | 1984-05-16 | — | — | EP | disclosed |